Based on research trials, about 50% of people see an improvement in depression symptoms after a single dose and about 60% experience reduced depression severity with 6 sessions.
When taken by mouth, ketamine shows about a 50% positive response rate for both depression and anxiety when used for 6 doses. Changes in depression symptoms can take 2 or more weeks.
No significant side effects have been seen with ketamine’s oral use, even when taken in varying doses over several days. The appropriateness of ketamine therapy is an individualized decision factoring in medical history, medications, and current symptoms. Successful treatment relies upon proper preparation and integration support.